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Coping With Narcolepsy: Tips to Stay Awake

Marco Gonzaga asked:




Sleeping during the course of the day is normal – especially when you do not have things to do and just want a bit of rest. However, it can be quite a problem if you succumb to daytime sleepiness at random times, particularly during hours when you should be working or concentrating on something. If these situations happen frequently enough, you could be suffering from narcolepsy. Here are some tips that can help you cope with narcolepsy:

1. Read up information on narcolepsy.

When you have some free time in your hands – meaning you’re not nodding off to sleep – read up about narcolepsy. Understanding your condition is key in finding the right solutions. For example, do you know that a person who suffers from narcolepsy is called narcoleptic and that imbalances in brain chemicals cause it? And one more thing – narcolepsy is incurable. It is a chronic disorder that needs a lifetime of management if you want to spend some time out of the bedroom. But despite it being incurable, it’ll help you to know that there are medications and techniques that can actually keep you awake when you want to. 

2. Be ready for symptoms.

A lot of narcolepsy symptoms get misdiagnosed as that of other more popular disorders such as anxiety, depression, and  drug abuse so it is important to pay attention. Symptoms of narcolepsy rarely come singly; most often than not, these signs come in pairs or in progression. Some symptoms to watch out for include overwhelming drowsiness and an uncontrollable need to sleep during the day, cataplexy (sudden loss of muscle tone which results in slurred speech and general muscle weakness), sleep paralysis (temporary inability to move or speak while falling asleep or upon waking.), and hallucinations. Restless nighttime sleep is also a symptom.

3. Address and treat symptoms.

Since managing narcolepsy largely depends in controlling its symptoms and causes, it is time to pay attention to these matters. Excessive daytime drowsiness or EDS can be prevented by establishing good nighttime sleep routines. If you are bothered by insomnia – which can make EDS worse – buying sleep aid drugs online can help. Just be sure to check with your doctor to ensure that no negative interactions will occur. EDS can also be fought off by using stimulants. On the other hand, antidepressants are also useful in preventing hallucinations. Just remember to follow your doctor’s prescription religiously to avoid overdosing and other complications. 

4. Practice preventive measures.

To stave off EDS, take short naps at strategic times during the day. These naps can help boost your alertness and prevent drowsiness for at least three hours. Avoiding nicotine and alcohol can also help a lot since they can cause other symptoms to worsen. It also helps to stick to a strict sleep schedule as this can help your body clock recognize between the right and wrong time to fall asleep. Exercising and eating a balanced diet can also prevent muscle loss and weakness. 

5. Form a support group.

Having a support from your workplace or school can significantly boost your chances of coping with narcolepsy. The American with Disabilities Act prohibits discrimination against narcoleptic workers and requires employers to provide reasonable accommodations to qualified employees. You can talk to your teacher or boss about taking short naps during the day, recording meetings and lectures, or breaking up monotonous tasks.



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Tramadol CLINICAL PHARMACOLOGY – Pharmacodynamics

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ULTRAM is a centrally acting synthetic analgesic compound. Although its mode of action is not completely understood, from animal tests, at least two complementary mechanisms appear applicable: binding of parent and M1 metabolite to m-opioid receptors and weak inhibition of reuptake of norepinephrine and serotonin.

Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O-demethylated metabolite M1 to m-opioid receptors. In animal models, M1 is up to 6 times more potent than tramadol in producinganalgesia and 200 times more potent in m-opioid binding.

Tramadol induced analgesia is only partially antagonized by the opiate antagonist naloxone in several animal tests. The relative contribution of both tramadol and M1 to human analgesia is dependent upon the plasma concentrations of each compound (see CLINICAL PHARMACOLOGY, Pharmacokinetics).

Tramadol has been shown to inhibit reuptake of norepinephrine and serotonin in vitro, as have some other opioid analgesics. These mechanisms may contribute independently to the overall analgesic profile of ULTRAM. Analgesia in humans begins approximately within one hour after administration and reaches a peak in approximately two to three hours.

Apart from analgesia, ULTRAM administration may produce a constellation of symptoms (including dizziness, somnolence, nausea, constipation, sweating and pruritus) similar to that of an opioid.

However, tramadol causes less respiratory depression than morphine at recommended doses (see OVERDOSAGE). In contrast to morphine, tramadol has not been shown to cause histamine release. At therapeutic doses, ULTRAM has no effect on heart rate, left-ventricular function or cardiac index. Orthostatic hypotension has been observed.

This page is provided for educational and informational purposes only and is not intended as a substitute for the advice of a medical doctor, nurse, nurse practitioner or other qualified health professional.